Treating bone metastases with local therapy in a breast cancer patient resulted in decreased pain and prevented fracture

David Palma, Nikhil Thakur, Joe C Loy & Bryan S Margulies.
Here, we report the case of a stage IV breast cancer patient with multiple lytic metastatic lesions to the spine that were successfully treated, which led to a significant reduction in pain and increased quality of life. This outcome demonstrates that a locally administered therapeutic intervention may represent an important alternative for patients with bone metastases that warrants further study.

Antagonism of the Met5-enkephalin-opioid growth factor receptor-signaling axis promotes MSC to differentiate into osteoblasts

Nikhil A. Thakur, Sean D. DeBoyace, Bryan S. Margulies.
OPRD, OGFR, and the met5-ligand were highly expressed in MSC and osteoblasts. A pulse-dose of naloxone increased mineral formation in MSC cultures in contrast to MSC treated with continuous naloxone or OGFR deficient MSC. Importantly, SMAD1 and SMAD8/9 expression increased after a pulse dose of naloxone whereas SMAD1, SMAD7, and ID1 were increased in the OGFR deficient MSC.

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Publications about Zetagen

Treating bone metastases with local therapy in a breast cancer patient resulted in decreased pain and prevented fracture

Antagonism of the Met5-enkephalin-opioid growth factor receptor-signaling axis promotes MSC to differentiate into osteoblasts